The following is a small sample of the information and
studies that help support the CVProfilor® science
and method:
1. Loss of Elasticity is a Marker for Atherosclerotic
Plaque Burden
Elasticity measurements can be used for identification
of patients with diffuse atherosclerotic processes of
the coronary arteries
Small Artery Elasticity was found to be an independent
predictor of coronary artery status as assessed by
angiogram
Syeda, B. et al, Arterial Compliance: A Diagnostic
Marker for Atherosclerotic Plaque Burden?, American
Journal of Hypertension, 16:356-362, 2003, ( U of
Vienna, Austria) Ref: 197
2. Loss of Small Artery Elasticity is Predictive of
Cardiovascular Events
For every 2-unit decrease in C2-Small Artery Elasticity
Index, there is a 50% increase in cardiovascular events
(p < .001)
Overall accuracy of C2-Small Artery Elasticity in
predicting likelihood of cardiac events = 76.8%
Occurrence of events as a function of baselinearterial
compliance:
N=419 subjects; 1 to 7 year follow-up
End points: MI, stroke, TIA, angina, coronary or
peripheral revascularization, coronary artery or
peripheral bypass graft, death
Grey, E. et.al, Small But Not Large Artery Compliance
Predicts Cardiovascular Events, American Journal of
Hypertension 16(No. 4), 265-269, 2003, (U of MN) Ref:
172
3. Repeatability of Arterial Elasticity Assessments
Healthy subjects from 7 European sites
Intra-visit measurements taken 5 minutes apart differed
by less than 3%
Inter-visit measurements taken 1-5 weeks later differed
by less than 4%
Conclusion: Measurement of AE is highly reproducible
despite the fact that BP and hemodynamic status was not
identical
Zimlichman, R. et. al, Determination of Arterial
Compliance Using Blood Pressure WaveformAnalysis with
the CR-2000 System, American Journal of Hypertension 18
(No.1):65-71, 2005
4). Small Artery Elasticity is a Sensitive Marker for
Endothelial Dysfunction
Type
Control
L-NAME
P Value
Blood Pressure
112/65
122/75
<0.01
Mean Arterial Pressure
80.2
90.4
<0.001
Pulse Wave Velocity
8.25
8.98
0.04
Brachial Artery Area1
10.8
11.0
NS
Brachial Artery Compliance1
0.0027
0.0049
0.07
Augmentation Index %
48.3
64.6
<0.05
Flow Mediated Vasodilatation
%1 5.29
4.47
0.06
C2 Small Artery Elasticity
2 9.9
6.9
<0.001
Systemic Vascular Resistance
2 1200
1487
<0.001
1 Measured using high-fidelity echo-tracking ultrasound
2 Measured using HD’s CardioVascular Profiling System
Gilani, M et al., Role of
nitric oxide deficiency and its detection as a risk
factor in prehypertension, Journal of the American
Society of Hypertension 1(No. 1), 45-55, 2007; Ref 261
5). American Society of
Hypertension Emphasizing Need to Go Beyond Blood Pressure
2005 definition of hypertension from ASH:
– Vascular abnormalities are central to the
identification and treatment of hypertension
– Need to identify where the patient is on the disease
continuum to individualize assessment and treatment
– Need global cardiovascular disease risk assessment,
need to go beyond lowering blood pressure
2007 ESH guidelines for treating hypertension now
include vascular assessment
Giles, T. et.al, Expanding the Definition and
Classification of Hypertension, The Journal of Clinical
Hypertension 7 (No. 9):505-512, Ref. 229A
